Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide

1:1 salt of Disopyramide (DPA) with Terephthalic acid (TA) was obtained by the slow solvent evaporation and slurry crystallization methods. X-ray single crystal diffraction DPA:TA confirmed formation transfer an acidic proton from one carboxylic groups TA to tertiary amino group chain moiety (N3-nitrogen atom) DPA molecules. crystals crystalize in triclinic system space P-1. The asymmetric unit, comprising protonated anion, are linked a strong charge assisted N+–H∙∙∙O¯ hydrogen bond C–H∙∙∙O¯ bond. Moreover, structural characterization carried out using Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, powder techniques